A synthetic peptide corresponding to aa's 4-14 of myelin basic protein

Potent inhibitor of PKC (Ki of 0.15 µM); no significant inhibition of cAMP-dependent protein kinases (IC50>400 µM)0.5 mg

Biologically active peptides

A peptide inhibitor for cAMP-dependent protein kinase (PKA)

A peptide substrate for ERK 1 and ERK 2 MAP kinases

peptide substrate for ERK 1 and ERK 2 MAP kinases, 0.5 mg/0.1 mlsequence: R R R E L V E P L T P S G E (>97% pure by HPLC)corresponds to amino acids 663-673 of EGFR including Thr 669 within the Pro-X-Ser/Thr Pro MAP kinase substrate consensus sequence (plus 3 NH-2-terminal Arg residues to confer basic charge)

peptide substrate for MEK (MAP kinase kinase) and tyrosine protein kinases such as Lck p56; Km for Lck p56 tyrosine phosphorylation 170 µM, 0.5 mg/0.1 mlsequence: A D P D H D H T G F L T E Y V A T R WRRcorresponds to amino acids 172-190 containing Thr 183 and Tyr 185 within the regulatory sequence common to ERK 1 and ERK 2 MAP kinases (plus 2 COOH terminal Arg residues)

peptide substrate for Ca++/calmodulin kinase II and Raf-1, 0.5 mg/0.1 mlsequence: PLARTLSVAGLPGKK (>97% pure by HPLC)

A peptide substrate for Akt/PKBα

synthetic substrate for CaM Kinase IV, 0.5 mg/0.1 mlsequence: KSDGGVKKRKSSSS (>97% pure by HPLC)corresponds to sequence derived from CaM Kinase IIγ

A highly selective peptide substrate for CaM Kinase II

A synthetic inhibitor for ARF that inhibits ARF-dependent ADP-ribosylation by cholera toxin

Synthetic activator of PLA2, 0.5 mg/0.1 mlsequence: ESPLIAKVLTTEPPIITPVRR (>97% pure by HPLC)derived from PLA2 activating protein PLAP

A synthetic activator of PI 3-kinase and an IRS-1 substrate

Blocks activation of CaM Kinase II

synthetic inhibitor of CaM Kinase II, 0.5 mg/0.1 mlsequence: MHRQEAVDCLKKFNARRKLKGA(>97% pure by HPLC)corresponds to sequence derived from CaM Kinase IIα; competes with ATP to inhibit CaM Kinase II

A synthetic substrate for cGKI

synthetic inhibitor of cGKI, 0.5 mg/0.1 mlsequence: RKRARKE (>97% pure by HPLC)corresponds to sequence derived from non-phosphorylatable analog of Histone H2B

A synthetic substrate for MLCK

synthetic substrate for MYLK2, 0.5 mg/0.1 mlsequence: AKRPQRATSNVFS (>97% pure by HPLC)Substrate for skeletal muscle myosin light chain kinase (MYLK2). Derived from avian smooth muscle myosin P-light chain with LysÆAla. of origin by

synthetic inhibitor for MYLK2, 0.5 mgsequence: KRRWKKNFIAV (>97% pure by HPLC)sequence derived from skeletal muscle light chain kinase, MYLK2, amino acids 342-352

synthetic substrate for casein kinase II, 0.5 mg/0.1 mlsequence: RREEETEEE (>97% pure by HPLC)Specific substrate for casein kinase II, not PKA, PKG, MLCK, RPTK or casein kinase I. Sequence based on casein kinase II phosphorylation sites in casein.

A synthetic substrate for insulin receptor

synthetic substrate for EGFR, 0.5 mg/0.1 mlsequence: RRLIEDNEYTARG (>97% pure by HPLC)residues 2-12 are derived from v-Src (412-422); substrate in A-431 cells

A synthetic inhibitor for Src and EGFR

A synthetic activator for Src family members

synthetic substrate for PP2B, 0.5 mg/0.1 mlsequence: DLDVPIPGRFDRRVSVAAE (>97% pure by HPLC)phospho-Ser 95-phosphate can be quantified using malachite green colorimetric assay

synthetic substrate for PP2B, 0.5 mg/0.1 mlsequence: DLDVPIPGRFDRRVSVAAE (>97% pure by HPLC)non-phosphorylated; can be radiolabeled by PKA

synthetic inhibitor for PP2B, 0.5 mg/0.1 mlsequence: ITSFEEAKGLDRINERMPPRRDAMP (>97% pure by HPLC)derived from PP2B auto-inhibitory domain from rat brain calcineuron A α, residues 457-482

synthetic substrate for Cdk2, 0.5 mg/0.1 mlsequence: QLQLQAASNFKSPVKTIR (>97% pure by HPLC)contains casein kinase autophosphorylation site plus Cdc2 p34 consensus phosphorylation site Ser 209. Also inhibits apoptosis induced by perforin.